GDMFS is designed to measure the total factor productivity (TFP) of manufacturing firms in Guangdong province and examine the impact of product quality on TFP growth. This survey interviewed nearly 600 and about 400 manufacturing firms in 2017 and 2018, respectively, across 14 cities in Guangdong province. It records detailed information on financial management, quality control, human capital, production, industrial robots, informatization and e-commerce of each firm. The data of 80% surveyed firms can be merged with the Annual Survey of Industrial Enterprises (ASIE) of China's National Bureau of Statistics, one of China’s most important databases of this kind.